Physical map of the Brucella melitensis 16 M chromosome

Global Analysis of Quorum Sensing Targets in the Intracellular Pathogen Brucella melitensis 16 M

Many pathogenic bacteria use a regulatory process termed quorum sensing (QS) to produce and detect small diffusible molecules to synchronize gene expression within a population. In Gram-negative bacteria, the detection of, and response to, these molecules depends on transcriptional regulators belonging to the LuxR family. Such a system has been discovered in the intracellular pathogen Brucella ...

Main Functions and Taxonomic Distribution of Virulence Genes in Brucella melitensis 16 M

Many virulence genes have been detected in attenuated mutants of Brucella melitensis 16 M; nevertheless, a complete report of these genes, including the main Cluster of Orthologous Groups (COG) represented as well as the taxonomical distribution among all complete bacterial and archaeal genomes, has not been analyzed. In this work a total of 160 virulence genes that have been reported in attenu...

The Chromosome 16 Physical Map: Ordering Quality Statistics

Studies on the nutrition of Brucella melitensis.

Koser, Breslove, and Doirfman (1941) obtained moderate growth (one billion cells per ml) of the three species, Brucella melitensis, Brucella abortus, and Brucella suis, in a chemically defined medium consisting of 17 amino acids, glucose, inorganic salts, thiamin, nicotinamide, biotin, and pantothenic acid. All of the strains studied required thiamin and nicotinamide, and all weere stimulated b...

Isolation, cloning and expression of the Brucella melitensis Omp31 gene

Brucellosis is a zoonotic disease transmitted to humans either from animals or from their products.Although brucellosis can be found worldwide, the Mediterranean Basin, South and Central America, EasternEurope, Asia, Africa, the Caribbean, and the Middle East have currently been listed as high-risk regions. Thegenus Brucella is classified in at least nine species. Brucella melitensis is the glo...